Journal article
Macroporous Hydrogels Composed Entirely of Synthetic Polypeptides: Biocompatible and Enzyme Biodegradable 3D Cellular Scaffolds
SJ Shirbin, F Karimi, NJA Chan, DE Heath, GG Qiao
Biomacromolecules | AMER CHEMICAL SOC | Published : 2016
Abstract
Synthetic polypeptides are a class of bioinspired polymers with well demonstrated biocompatibility, enzyme biodegradability, and cell adhesive properties, making them promising materials for the preparation of macroporous hydrogels as 3D cellular scaffolds. Three-dimensional macroporous hydrogels composed entirely of biocompatible and enzyme biodegradable synthetic polypeptides have thus been prepared. Under cryoconditions, macroporous hydrogels in the form of macroporous cryogels were prepared using a single copolymer component through direct EDC/sulfo-NHS zero-length cross-linking between poly(l-glutamic acid) (PLG) and poly(l-lysine) (PLL) residues on a PLG-r-PLL random copolypeptide chai..
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Awarded by Australian Research Council
Funding Acknowledgements
The authors would like to acknowledge the Australian Research Council (ARC) for funding in the form of a Discovery Project (DP140100002). S.J.S. would like to thank The University of Melbourne, the Commonwealth Scientific and Industrial Research Organization (CSIRO), and the Melbourne Materials Institute (MMI) for various scholarships. F.K. would like to thank the Australian Government and the University of Melbourne for an International Postgraduate Research Scholarship (IPRS).The authors would also like to thank Mr. Dunyin Gu for help with mechanical testing measurements and Mr. Ke Xie for help with ESEM measurements.